Postdoctoral Fellow - Shalapour Laboratory
Company: MD Anderson
Location: Houston
Posted on: May 28, 2023
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Job Description:
A postdoctoral fellow position is available in the Department of
Cancer Biology under the direct supervision of Dr. Shabnam
Shalapour. Research in the Shalapour Laboratory focuses on the role
of chronic inflammation and adaptive immunity in controlling tumor
development and the response of various cancers to therapy. While
the research focuses primarily on tumor immunology and
immunotherapy, our work also addresses fundamental questions in
immunology, immunometabolism, and cancer biology using cutting-edge
technology tools including multicolor Flow cytometry, CyTOF,
imaging, histology, and large-scale omic analysis, e.g.,
single-cell RNA and ATAC-seq.
The candidate will work on a project recently awarded by the
Melanoma Research Alliance (MRA) Team science award
(https://www.curemelanoma.org/research/grants/) collaboratively
funded by Brigham and Women's Hospital Harvard University and The
University of Texas MD Anderson Cancer Center with Title:
Harnessing B cell checkpoints in melanoma. The aim is to study the
role of B and plasma cells in melanoma. The focus then is on how to
use this information to prevent cancer development and develop
novel therapeutic approaches to increase the response to
immunotherapy and vaccination (see our recent publications; Semin
Immunol. 2021 Feb;52:10147; .PNAS, 2021 Feb 23;118(8):e2025840118,
Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9),
Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul
16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).
LEARNING OBJECTIVES
This postdoc fellowship will focus on the role of adaptive immune
cells, particularly B cells, in tumor immunology and how chronic
inflammation regulates their development and effector function,
using bioinformatic tools and genetically engineered mouse models
(GEMM) and state-of-the-art immunological and experimental
approaches.
ELIGIBILITY REQUIREMENTS
Applicants must have a recent PhD degree in a related biomedical
field, preferred immunology, or cancer biology with strong
interests and self-motivation for research.
Keywords: MD Anderson, Houston , Postdoctoral Fellow - Shalapour Laboratory, Healthcare , Houston, Texas
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