Research Investigator - Cancer Biology
Company: University of Texas M.D. Anderson
Location: Houston
Posted on: June 12, 2021
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Job Description:
MISSION STATEMENT The Cancer Biology department has a long history of being a
leader in the field of basic and translational cancer biology
research. The department emphasizes the training of students,
postdoctoral fellows and clinical fellows in the fundamentals of
tumor biology to improve the outcomes of patients with
malignancies. The department has built a program with close ties to
many clinical departments to facilitate information exchange
between the laboratory and the clinic. As such, faculty in the
department are investigators on NIH funded collaborative cancer
biology research grants. In addition, there are several
physician-scientists who have joint appointments in Cancer Biology,
facilitating the exchange of clinically-relevant information
between the laboratory and the clinic. SUMMARY The primary purpose of the Research Investigator is to work
independently and/or under the supervision of the PI in a highly
productive laboratory and to conduct research related to overcome
immune suppressive tumor microenvironment, define tumor intrinsic
resistance mechanisms to immunocheckpoint therapy and identify
synthetic lethal targets in a number of cancer types, including
brain cancer, colon cancer and prostate cancer. The Research Investigator is expected to conduct both cell
culture work and animal studies using many different types of
models, including 2D, 3D culture systems, organoids, PDX, GEMM and
rapid ES-derived GEMM, among others. In addition, it is expected
that the Research Investigator will gain expert level skills for
various techniques required to address a scientific question,
including CyTOF, imaging-CyTOF, scSeq, other omics and downstream
bioinformatic analysis in consultation with in house computational
scientists. As the goal of our research projects are translational, we
expect that the Research Investigator will actively participate in
collaborations with outstanding clinicians to potentially move the
bench discoveries to the clinics as exemplified by several ongoing
clinical trials in prostate cancer and colon cancer. Finally, the
Research Investigator are expected to support PI's grant
application as well as writing reviews and manuscripts through
which the Research Investigator will gain a deep understanding on
the art of scientific writing and presentation. The position
requires independent decision making, judgment and organizational
skills. Recent publications: (Zhao et al., Nature 2017; Lu et al.,
Nature 2017; Hu et al., Cell 2016; Liao et al., Cancer Cell 2019;
Chen et al., Cancer Cell 2019; Zhao et al., Cancer Discovery 2020;
Hou et al., Cancer Discovery 2020). JOB SPECIFIC COMPETENCIES Lab Studies Performing laboratory studies using complex techniques (e.g.
nucleic acid extraction, PCR, immunoblotting, immunocytochemistry and
immunohistochemistry) as well as tissue culture (maintaining mammalian cells, growth
assays). Presents data for analysis. In addition, both transgenic mice and transplantation
animal model, PDX etc are heavily used in the lab Experiment Design Assists the principal investigator with design of
experiments. Equipment Maintenance Responsible for equipment maintenance and coordinating repair of
malfunctioning units for lab. Orders Supplies Orders and organizes supplies (including tissue culture medium)
as needed. Project Results Compiles, writes and submits project results to PI. Study Immune Suppressive Microenvironment and Define Optimal
Therapeutic Approach for Patient Translation Imaging CyTOF and CyTOF, FACS analysis will be used extensively
to document the effect of various oncogenic events on tumor
microenvironment using various animal models, i.e. colon cancer,
prostate cancer and brain cancer. Synthetic Lethal Screening Targeted screening will be performed to define targets that
enhance immune checkpoint effect in vivo. In addition, synthetic
lethal screening will be performed on the above cancer types to
identify novel therapeutic targets followed by validation in
clinical samples. Education Required: Bachelor's degree in one of the natural sciences or
related field. Preferred: Master's degree in one of the natural sciences or
related field. Experience Required: Five years of experience in scientific or experimental
research work. With preferred degree, three years of required
experience. It is the policy of The University of Texas MD Anderson Cancer
Center to provide equal employment opportunity without regard to
race, color, religion, age, national origin, sex, gender, sexual
orientation, gender identity/expression, disability, protected
veteran status, genetic information, or any other basis protected
by institutional policy or by federal, state or local laws unless
such distinction is required by law.
http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Additional Information
Keywords: University of Texas M.D. Anderson, Houston , Research Investigator - Cancer Biology, Other , Houston, Texas
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